2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W010510R
    DL-Norvaline (Standard) 760-78-1
    DL-Norvaline (Standard) is the analytical standard of DL-Norvaline. This product is intended for research and analytical applications. DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
    DL-Norvaline (Standard)
  • HY-W010514R
    trans-Cyclohexane-1,2-diol (Standard) 1460-57-7 98%
    trans-Cyclohexane-1,2-diol (Standard) is the analytical standard of trans-Cyclohexane-1,2-diol (HY-W010514). This product is intended for research and analytical applications. trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells.
    trans-Cyclohexane-1,2-diol (Standard)
  • HY-W010594R
    Tetrahydrothiophen-3-one (Standard) 1003-04-9 98%
    Tetrahydrothiophen-3-one is an endogenous metabolite.Tetrahydrothiophen-3-one is a pharmaceutical intermediate that can be used to synthesize thiazole compounds. Tetrahydrothiophen-3-one exists in natural food and has good safety.
    Tetrahydrothiophen-3-one (Standard)
  • HY-W010736R
    1,2-Dipalmitoyl-sn-glycerol (Standard) 30334-71-5 98%
    1,2-Dipalmitoyl-sn-glycerol is an endogenous metabolite.
    1,2-Dipalmitoyl-sn-glycerol (Standard)
  • HY-W010832R
    Uridine-5'-diphosphate disodium salt (Standard) 27821-45-0 98%
    Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
    Uridine-5'-diphosphate disodium salt (Standard)
  • HY-W010973R
    5-Hydroxytryptamine creatinine sulfate monohydrate (Standard) 61-47-2 98%
    5-Hydroxytryptamine creatinine sulfate monohydrate (Standard) is the analytical standard of 5-Hydroxytryptamine creatinine sulfate monohydrate (HY-W010973). This product is intended for research and analytical applications. 5-Hydroxytryptamine creatinine sulfate monohydrate is an endogenous metabolite.
    5-Hydroxytryptamine creatinine sulfate monohydrate (Standard)
  • HY-W011086R
    Tri-O-tolyl phosphate (Standard) 78-30-8 98%
    Tri-O-tolyl phosphate (Tri-O-cresyl phosphate; TOTP) (Standard) is an analytical standard of Tri-O-tolyl phosphate (HY-W011086). This product is intended for research and analytical applications. Tri-O-tolyl phosphate is an aryl phosphate compounds commonly utilized as flame retardants and lubricant additives across various industrie. Tri-O-tolyl phosphate has neurotoxicity and reproductive toxicity, decreasing cell viability, inhibiting cell proliferation, triggering cell cycle arrest, induceing apoptosis, causing mitochondrial dysfunction, disrupts calcium homeostasis.
    Tri-O-tolyl phosphate (Standard)
  • HY-W011120R
    Ethyl docosa-4,7,10,13,16,19-hexaenoate (Standard) 84494-72-4
    Ethyl docosa-4,7,10,13,16,19-hexaenoate (Standard) is the analytical standard of Ethyl docosa-4,7,10,13,16,19-hexaenoate. This product is intended for research and analytical applications. Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is enriched in the ethyl ester fraction by the selective alcoholysis of fatty acid ethyl esters originating from tuna oil with lauryl alcohol.
    Ethyl docosa-4,7,10,13,16,19-hexaenoate (Standard)
  • HY-W011175R
    Batilol (Standard) 544-62-7
    3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite.
    Batilol (Standard)
  • HY-W011195R
    Calcium 2-hydroxy-4-(methylthio)butanoate (Standard) 4857-44-7 98%
    Calcium 2-hydroxy-4-(methylthio)butanoate (Standard) is the analytical standard of Calcium 2-hydroxy-4-(methylthio)butanoate (HY-W011195). This product is intended for research and analytical applications. Calcium 2-hydroxy-4-(methylthio)butanoate is an endogenous metabolite.
    Calcium 2-hydroxy-4-(methylthio)butanoate (Standard)
  • HY-W011240R
    Hydroflumethiazide (Standard) 135-09-1
    Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas.
    Hydroflumethiazide (Standard)
  • HY-W011249R
    Phosphorylcholine chloride calcium salt tetrahydrate (Standard) 72556-74-2 98%
    Phosphorylcholine chloride (calcium salt tetrahydrate) (Standard) is the analytical standard of Phosphorylcholine chloride (calcium salt tetrahydrate) (HY-W011249). This product is intended for research and analytical applications. Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.
    Phosphorylcholine chloride calcium salt tetrahydrate (Standard)
  • HY-W011690R
    L-Homocystine (Standard) 626-72-2 98%
    L-Homocystine (Standard) is the analytical standard of L-Homocystine (HY-W011690). This product is intended for research and analytical applications. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
    L-Homocystine (Standard)
  • HY-W011711R
    Benzarone (Standard) 1477-19-6 98%
    Benzarone (Standard) is the analytical standard of Benzarone. This product is intended for research and analytical applications. Benzarone is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels.
    Benzarone (Standard)
  • HY-W011727R
    Pyridoxal 5'-phosphate hydrate (Standard) 853645-22-4 98%
    Pyridoxal 5'-phosphate (hydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (hydrate) (HY-W011727). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP).
    Pyridoxal 5'-phosphate hydrate (Standard)
  • HY-W011978R
    N-Acetyl-L-tryptophan (Standard) 1218-34-4 99.99%
    N-Acetyl-L-tryptophan (Standard) is the analytical standard of N-Acetyl-L-tryptophan. This product is intended for research and analytical applications. N-Acetyl-L-tryptophan is an endogenous metabolite.
    N-Acetyl-L-tryptophan (Standard)
  • HY-W012092R
    Ethyl 3,4,5-trimethoxybenzoate (Standard) 6178-44-5 98%
    Ethyl 3,4,5-trimethoxybenzoate is a natural compound isolated from the roots of Rauvolfia yunnanensis Tsiang. Ethyl 3,4,5-trimethoxybenzoate is a melanogenesis inhibitor. Ethyl 3,4,5-trimethoxybenzoate does not directly target tyrosinase activity, but inhibits melanin synthesis in a dose-dependent manner by downregulating α-MSH (HY-P0252)-induced tyrosinase protein expression and scavenging ROS. Ethyl 3,4,5-trimethoxybenzoate scavenges DPPH free radicals. Ethyl 3,4,5-trimethoxybenzoate can be used in the research of hyperpigmentation.
    Ethyl 3,4,5-trimethoxybenzoate (Standard)
  • HY-W012340R
    H-HomoArg-OH.HCl (Standard) 1483-01-8
    H-HomoArg-OH.HCl is an endogenous metabolite.
    H-HomoArg-OH.HCl (Standard)
  • HY-W012479R
    H-D-Trp-OH (Standard) 153-94-6 98%
    H-D-Trp-OH (Standard) is the analytical standard of H-D-Trp-OH. This product is intended for research and analytical applications. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.
    H-D-Trp-OH (Standard)
  • HY-W012480R
    DL-Tryptophan (Standard) 54-12-6 98%
    DL-Tryptophan is an endogenous metabolite.
    DL-Tryptophan (Standard)
Cat. No. Product Name / Synonyms Application Reactivity